ramena sardham mathuram pranite
svaphalkina mayy anurakta-cittah
vigadha-bhavena na me viyoga-
tivradhayo ’nyam dadrsuh sukhaya
The residents of Vrndavana, headed by the gopis, were always completely attached to Me with deepest love. Therefore, when My uncle Akrura brought My brother Balarama and Me to the city of Mathura, the residents of Vrndavana suffered extreme mental distress because of separation from Me and could not find any other source of happiness.
This verse especially describes the sentiments of the cowherd girls of Vrndavana, the gopis, and Lord Krsna here reveals the incomparable love they felt for Him. As explained in the Tenth Canto, Lord Krsna’s uncle Akrura, sent by Kamsa, came to Vrndavana and took Krsna and Balarama back to Mathura for a wrestling event. The gopis loved Lord Krsna so much that in His absence their consciousness was completely absorbed in spiritual love. Thus their Krsna consciousness is considered the highest perfectional stage of life. They were always expecting that Lord Krsna would finish His business of killing demons and return to them, and therefore their anxiety was an extremely moving, heartrending display of love. Anyone desiring true happiness must take to the devotional service of the Lord in the spirit of the gopis, giving up everything for the pleasure of the Supreme Lord.