A purified soul should see that because the conditioned souls who are dedicated to sense gratification have falsely accepted the objects of sense pleasure as truth, all of their endeavors are doomed to failure.
In this verse the Lord describes the process of becoming desireless. All material sense objects, including those perceived by their form, taste, flavor, touch or sound, are temporary. We now see our family and nation, but ultimately they will disappear. Even our own body, by which we perceive them, will disappear. Thus, the inevitable result of material enjoyment is viparyaya, or great suffering. The word visuddhatma indicates those who have purified themselves by executing the regulative duties of devotional service. They can clearly see the hopeless frustration of material life, and thus they become akamatma, or great souls free from material desire.