kim asat-karmabhir bhavet
Translation by His Divine Grace A. C. Bhaktivedanta Swami Srila Prabhupada:
[Narada Muni had said that there is a house made of twenty-five elements. The Haryasvas understood this analogy.] The Supreme Lord is the reservoir of the twenty-five elements, and as the Supreme Being, the conductor of cause and effect, He causes their manifestation. If one engages in temporary fruitive activities, not knowing that Supreme Person, what benefit will he derive?
Purport by His Divine Grace A. C. Bhaktivedanta Swami Srila Prabhupada:
Philosophers and scientists conduct scholarly research to find the original cause, but they should do so scientifically, not whimsically or through fantastic theories. The science of the original cause is explained in various Vedic literatures. Athato brahma jijñasa/janmady asya yatah. The Vedanta-sutra explains that one should inquire about the Supreme Soul. Such inquiry about the Supreme is called brahma jijñasa. The Absolute Truth, tattva, is explained in Srimad-Bhagavatam (1.2.11):
vadanti tat tattva-vidas
tattvam yaj jñanam advayam
bhagavan iti sabdyate
“Learned transcendentalists who know the Absolute Truth call this nondual substance Brahman, Paramatma or Bhagavan.” The Absolute Truth appears to neophytes as impersonal Brahman and to advanced mystic yogis as Paramatma, the Supersoul, but devotees, who are further advanced, understand the Absolute Truth as the Supreme Lord, Visnu.
This material cosmic manifestation is an expansion of the energy of Lord Krsna, or Lord Visnu.
jyotsna vistarini yatha
parasya brahmanah saktis
tathedam akhilam jagat
“Whatever we see in this world is but an expansion of various energies of the Supreme Personality of Godhead, who is like a fire that spreads illumination for a long distance although it is situated in one place.” (Visnu Purana) The entire cosmic manifestation is an expansion of the Supreme Lord. Therefore if one does not conduct research to find the supreme cause, but instead falsely engages in frivolous, temporary activities, what is the use of demanding recognition as an important scientist or philosopher? If one does not know the ultimate cause, what is the use of his scientific and philosophical research?
The purusa, the original person — Bhagavan, Visnu — can be understood only by devotional service. Bhaktya mam abhijanati yavan yas casmi tattvatah: only by devotional service can one understand the Supreme Person, who is behind everything. One must try to understand that the material elements are the separated, inferior energy of the Lord and that the living entity is the Lord’s spiritual energy. Whatever we experience, including matter and the spirit soul, the living force, is but a combination of two energies of Lord Visnu — the inferior energy and the superior energy. One should seriously study the facts concerning creation, maintenance and devastation, as well as the permanent place from which one never need return (yad gatva na nivartante). Human society should study this, but instead of culturing such knowledge, people are attracted to temporary happiness and sense gratification, culminating in bottomless, topless passion. There is no profit in such activities; one must engage himself in the Krsna consciousness movement.