Srimad Bhagavatam Canto 04, Chapter 21, Text 32

SB 4.21.32

vinirdhutasesa-mano-malah puman
yad-anghri-mule krta-ketanah punar
 na samsrtim klesa-vaham prapadyate
Translation by His Divine Grace A. C. Bhaktivedanta Swami Srila Prabhupada:
When a devotee takes shelter at the lotus feet of the Supreme Personality of Godhead, he is completely cleansed of all misunderstanding or mental speculation, and he manifests renunciation. This is possible only when one is strengthened by practicing bhakti-yoga. Once having taken shelter at the root of the lotus feet of the Lord, a devotee never comes back to this material existence, which is full of the threefold miseries.
Purport by His Divine Grace A. C. Bhaktivedanta Swami Srila Prabhupada:
As stated by Lord Caitanya Mahaprabhu in His Siksastaka instructions, by the chanting of the holy name of the Lord — Hare Krsna, Hare Krsna, Krsna Krsna, Hare Hare/ Hare Rama, Hare Rama, Rama Rama, Hare Hare — or by the process of hearing and chanting of the glories of the Lord, one’s mind is gradually cleansed of all dirt. Due to our material association since time immemorial, we have accumulated heaps of dirty things in our minds. The total effect of this takes place when a living entity identifies himself with his body and is thus entrapped by the stringent laws of material nature and put into the cycle of repeated birth and death under the false impression of bodily identification. When one is strengthened by practicing bhakti-yoga, his mind is cleansed of this misunderstanding, and he is no longer interested in material existence or in sense gratification.
Bhakti, or devotional service, is characterized by vairagya and jñana. Jñana refers to understanding that one is not his body, and vairagya means disinterest in sense gratification. These two primary principles of separation from material bondage can be realized on the strength of bhakti-yoga. Thus when a devotee is fixed in the loving service of the lotus feet of the Lord, he will never come back to this material existence after quitting his body, as confirmed in Bhagavad-gita by the Lord (tyaktva deham punar janma naiti mam eti so ’rjuna).
In this verse the word vijñana is specifically important. Jñana, the knowledge of spiritual identity that one attains when he does not consider himself to be the body, is explained in Bhagavad-gita as brahma-bhuta, the revival of spiritual realization. In the conditioned state of material existence one cannot be spiritually realized because he identifies himself materially. The understanding of the distinction between material existence and spiritual existence is called jñana. After coming to the platform of jñana, or the brahma-bhuta state, one ultimately comes to devotional service, in which he completely understands his own position and the position of the Supreme Personality of Godhead. This understanding is explained here as vijñana-visesa. The Lord says, therefore, that knowledge of Him is vijñana, science. In other words, when one is strengthened by scientific knowledge of the Supreme Personality of Godhead, his position of liberation is guaranteed. In Bhagavad-gita (9.2), the science of devotional service is described as pratyaksavagamam dharmyam, direct understanding of the principles of religion by realization.
By practicing bhakti-yoga, one can directly perceive his advancement in spiritual life. In other practices — like karma-yoga, jñana-yoga and dhyana-yoga — one may not be confident about his progress, but in bhakti-yoga one can become directly aware of his progress in spiritual life, just as a person who eats can understand that his hunger is satisfied. Our false appetite for enjoyment and lordship of the material world is due to a prominence of passion and ignorance. By bhakti-yoga these two qualities are diminished, and one becomes situated in the mode of goodness. Gradually surpassing the mode of goodness, one is situated in pure goodness, which is not contaminated by the material qualities. When thus situated, a devotee no longer has any doubts; he knows that he will not come back to this material world.
Srimad Bhagavatam Canto 04, Chapter 21, Text 31
Srimad Bhagavatam Canto 04, Chapter 21, Text 33