pratikriya na yasyeha
kutascit karhicit prabho
sa esa bhagavan kalah
sarvesam nah samagatah
Translation by His Divine Grace A. C. Bhaktivedanta Swami Srila Prabhupada:
This frightful situation cannot be remedied by any person in this material world. My lord, it is the Supreme Personality of Godhead as eternal time [kala] that has approached us all.
Purport by His Divine Grace A. C. Bhaktivedanta Swami Srila Prabhupada:
There is no superior power which can check the cruel hands of death. No one wants to die, however acute the source of bodily sufferings may be. Even in the days of so-called scientific advancement of knowledge, there is no remedial measure either for old age or for death. Old age is the notice of the arrival of death served by cruel time, and no one can refuse to accept either summon calls or the supreme judgment of eternal time. This is explained before Dhrtarastra because he might ask Vidura to find out some remedial measure for the imminent fearful situation, as he had ordered many times before. Before ordering, however, Vidura informed Dhrtarastra that there was no remedial measure by anyone or from any source in this material world. And because there is no such thing in the material world, death is identical with the Supreme Personality of Godhead, as it is said by the Lord Himself in the Bhagavad-gita (10.34).
Death cannot be checked by anyone or from any source within this material world. Hiranyakasipu wanted to be immortal and underwent a severe type of penance by which the whole universe trembled, and Brahma himself approached him to dissuade Hiranyakasipu from such a severe type of penance. Hiranyakasipu asked Brahma to award him the blessings of immortality, but Brahma said that he himself was subject to death, even in the topmost planet, so how could he award him the benediction of immortality? So there is death even in the topmost planet of this universe, and what to speak of other planets, which are far, far inferior in quality to Brahmaloka, the residing planet of Brahma. Wherever there is the influence of eternal time, there is this set of tribulations, namely birth, disease, old age and death, and all of them are invincible.