yada mano-hrdaya-granthir asya
karmanubaddho drdha aslatheta
tada janah samparivartate ’smad
muktah param yaty atihaya hetum
Translation by His Divine Grace A. C. Bhaktivedanta Swami Srila Prabhupada:
When the strong knot in the heart of a person implicated in material life due to the results of past action is slackened, one turns away from his attachment to home, wife and children. In this way, one gives up the basic principle of illusion [I and mine] and becomes liberated. Thus one goes to the transcendental world.
Purport by His Divine Grace A. C. Bhaktivedanta Swami Srila Prabhupada:
When, by associating with sadhus and engaging in devotional service, one is gradually freed from the material conception due to knowledge, practice and detachment, the knot of attachment in the heart is slackened. Thus one can get freed from conditional life and become eligible to return home, back to Godhead.